With Major Wall Street Interest in Neuroscience Companies, Small-Cap Player NMTC is Gaining Speed….
Greetings Investors,
Arguably one of the hottest topics in biotech in recent years has been Biogen's (NASDAQ: BIIB) groundbreaking Alzheimer's treatment aducanumab.
It is currently under review by the FDA for approval and if it is approved, would be the first-ever drug to slow the progression of this killer disease.
This only highlights the growing need for developments in neuroscience that target neurological disorders.
With the growing epidemic of neurological disorders from Epilepsy to Parkinson's Disease, and even chronic back pain and depression… it has become apparent to pay close attention to the companies tackling such disorders!
NeuroOne Medical Technologies Corp. (NASDAQ: NMTC) is an emerging and exciting player on the NASDAQ that is doing exactly just this!
How is this essentially undiscovered company potentially about to revolutionize healthcare? NMTC has developed a breakthrough thin-film electrode.
The company is focused on treating Epilepsy, Parkinson's Disease, chronic back pain from failed surgeries, dystonia, and many other related neurological disorders.
Thanks to strategic partnerships with the Mayo Clinic and Zimmer Biomet
(NYSE:ZBH, ~$22B+ Mkt Cap), the company anticipates that their technologies will be widely adopted in the near future.
You know when the Mayo Clinic gets involved… it means something.
Trading at under $3.00 makes NMTC a growth story in the biotech space to keep your eyes on!
NeuroOne Medical Technologies Corp.
Advancing Neuroscience!
"Neuroscience is the next great frontier in medicine. I think we're on the cusp of some major breakthroughs in this space."
- Casper Hoogenraad, Genentech (VP, Neuroscience) June 2021
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NMTC is a developmental stage company committed to providing minimally invasive and hi-definition solutions for EEG recording, brain stimulation and ablation solutions for patients suffering from epilepsy, Parkinson's disease, dystonia, essential tremors, chronic pain due to failed back surgeries and other related neurological disorders that may improve patient outcomes and reduce procedural costs.
HIGHLIGHTS:
- Highly disruptive – step change technology improvement
- Platform technology with broad diagnostic and therapeutic applications
- Strategic partnerships with Zimmer Biomet and Mayo Clinic
Technology Value Proposition
We think, feel, move and sense through a web of 80+ billion neurons in the brain which communicate through electrical signals.
Electrodes are used to detect, record and monitor neurological activity and stimulate or ablate tissue to regulate brain activity.
NMTC is developing and perfecting high-definition, minimally invasive Evo® Cortical Electrodes for the diagnosis and treatment of various neurological conditions.
Why should this breakthrough company be on your watchlist?
First, there is substantial market opportunity. Second, these are disruptive patented technologies. Third, the technology addresses a significant and unmet need and
there could be substantially improved outcomes.
AND… these are already FDA cleared electrodes!
In November of 2019, NMTC had received 510(k) clearance for Evo Cortical Electrode technology for temporary (less than 30 days) recording, monitoring, and stimulation on the surface of the brain!
"On August 9th we re-submitted to the FDA a special 510(k) seeking clearance for <30 day use. In addition, we were excited to have the first Evo sEEG case performed by Dr. Robert Gross of Emory University for less than 24 hour use."
- Dave Rosa, CEO of NeuroOne
BRIDGING THE GAP – ARTIFICIAL INTELLIGENCE
§ Damaged neurons can cause a break in neuron-to-neuron connectivity: etiology for many neurological disorders.
§ Successful treatments achieved by implanting small wires to record and reintroduce the natural signal.
§ Elon Musk and others have started companies to try to implant millions of wires in the brain.
§ NeuroOne's high-definition thin film platform could allow for recording and stimulation of the neurons to bridge these gaps more effectively.
§ NeuroOne technology is scalable allowing thousands of contacts to be implanted.
Zimmerman Development Agreement
Zimmer Biomet, one of the world's most highly respected medical device manufacturers!
- Zimmer to exclusively commercialize and distribute NMTC's Evo ® electrode technology
- Agreement signed in July 2020, $2 million upfront payment with additional milestones
- Zimmer is a worldwide leader in robotic technology used in minimally invasive neurosurgeries
- Evo® electrode product line complementary to Zimmer's ROSA ONE® Brain platform
- Partnership enables efficient deployment into the market
- Allows NeuroOne to focus on development and pursue additional applications for technology Development and Distribution Agreement with Zimmer Biomet, one of the world's most highly respected medical device manufacturers
Zimmer Biomet agreed to an accelerated $3.5M milestone payment for the Evo® sEEG electrode. This amendment to our agreement provides NeuroOne with near term capital without the need for a highly dilutive financing and reinforces their ongoing partnership with Zimmer Biomet."
MAYO CLINIC PARTNERSHIP
- Mayo Clinic began testing technology in pre-clinical models and clinical research in 2015
- Mayo Clinic leading neurologist, Dr. Worrell, chairs the NeuroOne Scientific Advisory Board
- First commercial human use of Evo® Cortical Electrodes performed at Mayo Clinic in November 2020 Mayo Clinic partnership with NeuroOne began in 2017
DEVELOPMENTS
NMTC announced that it has successfully completed initial pre-clinical long-term testing of recording capabilities on its platform thin film electrode technology.
In test procedures, the electrodes' ability to record electrical activity over a span of 5 years was measured using an accelerated aging test model.
The test results demonstrated NMTC's thin film electrodes' reliability against environmental factors that may contribute to device failure or malfunction, which is a well-established
challenge with thin film electrode technology.
NMTC is also advancing a pipeline of therapeutic electrode technologies for brain tissue ablation, chronic stimulation use for DBS (deep brain stimulation) and spinal cord
stimulation for chronic back pain.
The Company believes these therapeutic electrode technologies are targeted to addressable markets of over $10 billion!
NMTC expects to release long-term data in the near future…
Q3 Milestones
· Completed ablation system prototypes, including RF generator from RBC Medical and NeuroOne's electrodes and accessories, ahead of schedule and successfully tested the first fully integrated sEEG/RF ablation system.
· Achieved major milestone with first sEEG electrode case for intraoperative brain mapping at the subsurface level of the brain performed at Emory University.
· Qualified second source for manufacturing for both the Evo cortical and sEEG electrodes.
· Completed validation and placed orders for a new cable assembly which will provide significant cost reduction.
· Established advisory board of leading anesthesiologists and neurosurgeons for spinal cord stimulation program.
· Completed design verification to extend shelf life for Evo cortical electrodes to three years.
· Presented at the HC Wainwright Global Investment Conference and the NobleCon 18 Investor Conference.
· Exhibited the Evo Cortical electrode family in partnership with Zimmer Biomet at the American Association of Neurological Surgeons Annual Scientific Meeting and the American Society for Stereotactic and Functional Neurosurgery Biennial Meeting.
· The first peered-reviewed paper presenting the biocompatibility results for NeuroOne subdural thin film electrodes was published in the Frontiers of Neuroscience journal on April 29, 2022.
· The Company's Evo sEEG implantation accuracy study was accepted as a podium presentation at the Biennial Meeting of the World Society for Stereotactic & Functional Neurosurgery, to be held in South Korea September 4-7 2022.
Upcoming Targeted Milestones
· Evo sEEG Depth Diagnostic Electrode
· OneRF(RF ablation system)
· Partner with a research organization to develop electrode for new clinical indication.
· Chronic Use Electrode
The Bottom Line
According to Global Market Insights, today there is a massive $13.6 billion neurostimulation devices market developing for the ongoing study of the vast arrays of the brain's neural
connections.
The diagnostic electrode technology currently used to detect neurological disorders is the same that was developed way back in the 1960s.
NMTC is truly not just any medtech company…
Not when both Evo Cortical and sEEG Electrodes are BOTH FDA approved!
Both the Mayo and Cleveland Clinic have conducted preclinical studies, which have produced promising results utilizing the company's devices in humans and/or animals.
Zimmer Biomet commercial launch was initiated just last year!
All of this reads like a recipe for success and NMTC may beone of the most exciting narratives to emerge on the NASDAQ!
PLUS, the company has cash on hand at $10.2M as of June 30th and NO DEBT OUTSTANDING!
Start your research right away!
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